Übersichtsarbeiten - OUP 04/2014

Flexiseq (TDT 064) zur Behandlung der schmerzhaften Kniegelenkarthrose

6. McGettigan P, Henry H. Use of non-steroidal anti-inflammatory drugs that elevate cardiovascular risk: an examination of sales and essential medicines in low-, middle-, and high-income countries. PLOS Medicine 2013; 10: e1001388. doi:10.1371/journal.pmed.1001388

7. Thiem U, Friedrich C, Pientka L. Klinik für Altersmedizin und Frührehabilitation der Ruhr-Universität Bochum, Marienhospital Herne: Repräsentative Studie zu Gelenkbeschwerden u. Osteoarthrose: Die Herner Arthrose-Studie (HER-AS) 2007

8. Cevc G, Vierl U. Nanotechnology and the transdermal route. A state of the art review and critical appraisal. J Control Release 2010; 141: 277–99

9. Cevc G, Mazgareanu S, Rother M. Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels. Int J Pharm 2008; 360: 29–39

10. Dominicus R, Weidner C, Tate H et al. Open-label study of the efficacy and safety of topical treatment with TDT 067 (terbinafine in Transfersome®) in patients with onychomycosis. Br J Dermatol 2012; 166: 1360–1362

11. Kneer W, Rother I, Rother M et al. A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin® (ketoprofen in Transfersome®) in joint/musculoskeletal pain or soft tissue inflammation. Curr Drug Saf 2009; 4: 5–10

12. Stucki G, Rother M for the European IDEA-033 Study Group. Randomized, double-blind, placebo-controlled study of three dosages of epicutaneously applied IDEA-033 (ketoprofen in Transfersome®) in patients with osteoarthritis of the knee. Ann Rheum Dis 2007; 6 (Suppl II), 510

13. Rother M, Lipetz R, Dunmyer S. A double-blind, randomised, placebo-controlled trial to evaluate the safety and efficacy of epicutaneously applied ketoprofen in Transfersome gel for the treatment of pain associated with osteoarthritis (OA) of the knee. Annual EULAR Congress, Berlin, Germany, 6?9 June. Abstract no. EULAR12–3378. 2012a

14. Rother M, Yeoman G, Ekman E. A double-blind, placebo-controlled trial comparing the safety and efficacy of epicutaneously applied ketoprofen in Transfersome gel with naproxen for the treatment of pain associated with osteoarthritis (OA) of the knee. Annual EULAR Congress, Berlin, Germany, 6?9 June. Abstract no. EULAR12–3375. 2012b

15. Colditz GA, Miller JN, Mosteller F. Measuring gain in the evaluation of medical technology. The probability of a better outcome. Int J Technol Assess Health Care 1988;4: 637–42

16. Conaghan PG, Dickson J, Bolten W et al. A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. Rheumatology (Oxford). 2013 Mar 28. [Epub ahead of print]

17. Rother M, Mazgareanu S, Vierl U et al. The impact of investigational site quality to prove effects on pain in clinical studies of osteoarthritis of the knee. J. Osteoarthritis and Cartilage 2010; 18 Suppl. 2: S223

18. Cohen J. Statistical power analysis for the behavioural sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associate Publishers, 1988

19. Zhang W, Robertson J, Jones AC et al. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis 2008; 67: 1716–1723

Fussnoten

1 Orthopädisch-unfallchirurgische Praxis, Stockach

2 IMR Partner GmbH, Gräfelfing

3 Rheumaklinik, Klaus-Miehlke-Klinik, Wiesbaden

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